A Neurocognitive Model of Anorexia Nervosa

New York State Psychiatric Institute152 enrolled

Overview

The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.

Patients with Anorexia Nervosa (AN) have extreme difficulty changing their eating behavior, even when they express desire for change. These behaviors seem to override all other potential responses, and can appear perseverative, or habitual. The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.

Study Type

OBSERVATIONAL

Enrollment

152

Conditions

Anorexia Nervosa

Eligibility

Sex: ALLMin age: 16 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion: * DSM-IV-TR™ diagnosis of anorexia nervosa (restricting or binge-purge subtype), current or prior; * Age 16-45; * Inpatient on GCRU * Medically stable. Exclusion: * Any other current major Axis I disorder (including current bulimia nervosa), except major depression; * History of concussion, seizure disorder, or other neurological illness; * History of learning disability; * Acute Suicidality Healthy comparison group: Inclusion: * No current or past psychiatric illness; * Age 16-45 * No history of binge eating or vomiting; * Normal weight (80%-120% ideal body weight) Exclusion: * Significant medical or neurologic illness(concussion, seizure disorder, learning disability, other neurological illness) * Current psychotropic medication or medications known to impact cognition Additional Exclusion Criteria for fMRI: * Significant Claustrophobia * Pregnancy * Indwelling metallic object, non-removable metal jewelry, medicinal patch or recent metallic ink tattoo * For patients, current psychotropic medications (antidepressants for 2 week (prozac and antipsychotics for 4 weeks) * For patients, any other current Axis I diagnosis

Outcomes

Primary Outcomes

Neuropsychological functioning

Time frame: pre- and post-treatment

Data from ClinicalTrials.gov

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