The purpose of this study is to evaluate the efficacy of quetiapine SR in combination with an antidepressant versus an antidepressant alone in patients with MDD with inadequate response to an antidepressant treatment. PLEASE NOTE: Seroquel SR and Seroquel XR refer to the same formulation. The SR designation was changed to XR after consultation with FDA.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
450
To evaluate the efficacy of quetiapine SR in combination with an antidepressant versus an antidepressant alone in MDD patients with inadequate response to an antidepressant treatment as assessed by the change from randomization to week 6 in the MADRS
To evaluate if quetiapine SR in combination with an antidepressant improves health-related quality of life of patients with MDD, compared to an antidepressant alone
To evaluate if quetiapine SR in combination with an antidepressant reduces anxiety symptoms in patients with MDD, compared to an antidepressant alone
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Research Site
Phoenix, Arizona, United States
Research Site
El Centro, California, United States
Research Site
Irvine, California, United States
Research Site
Oceanside, California, United States
Research Site
San Diego, California, United States
Research Site
Pueblo, Colorado, United States
Research Site
Coral Springs, Florida, United States
Research Site
DeLand, Florida, United States
Research Site
Gainsville, Florida, United States
Research Site
Hialeah, Florida, United States
...and 46 more locations