Extracorporal shock wave therapy is performed prior to cell therapy for induction of therapeutic neovascularization and improvement of homing of bone marrow progenitor cells in patients with chronic ischemic heart disease following anterior myocardial infarction. Shock waves can induce growth factor expression in the ischemic myocardium and might augment homing of autologous bone marrow mononuclear cells which are injected intracoronary 24 h following shock wave therapy
Single center, Phase I-II Study (Safety, Feasibility and Efficacy) Double-blind, randomised trial (Cell therapy), single blind (Shockwave)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
103
extracorporal shock waves prior to intracoronary cell therapy
Div. of Cardiology , University of Frankfurt
Frankfurt, Germany
Improvement in global ejection fraction on LV angiography
Time frame: 4 months
Global or regional wall motion at 4 months and 1 year
Time frame: 4 months
NYHA Class
Time frame: 4 months
NT BNP levels
Time frame: 4 months
MACE
Time frame: 4 months
Life quality
Time frame: 4 months
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