Inhaled TPI-1020 Versus Inhaled Budesonide in Smokers With Mild Reversible Asthma

Inclusion Criteria: * Males or females 18 through 65 years of age. * Smoking history of more than 5 pack/years but less than 25 pack/years and who have no desire to quit smoking despite physician's advice and who currently smoke at least 5 cigarettes per day. * Mild to moderate, stable, allergic asthma as defined by American Thoracic Society (ATS) criteria 1 * History of episodic wheeze and shortness of breath * Subjects currently and only receiving inhaled short-acting bronchodilator treatment for asthma. Exclusion Criteria: * History or symptoms of significant autoimmune, hematological, or neurological disease, including transient ischemic attack (TIA), stroke, seizure disorder, or behavioural disturbances that are judged clinically significant by the Investigator * History of serious adverse reaction or hypersensitivity to corticosteroids * Abnormal chest X-ray that is judged clinically significant * Pregnant or lactating or have positive plasma pregnancy test * Use of oral/parenteral/inhaled corticosteroids within the last 28 days or injectable depot corticosteroids within the last 6 weeks. * Use of any other asthma-related medications within 1 month of Screening