Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer

Carol Fabian, MD

Overview

A study to examine the potential associations between common single nucleotide polymorphisms and pre-cancerous conditions in breast tissue specimens from postmenopausal women.

A study to examine the correlation between single nucleotide polymorphisms (SNPs) affecting steroid and carcinogen metabolism and benign breast tissue cytomorphology collected via random periareolar fine needle aspiration in postmenopausal women at increased risk for breast cancer and taking hormone replacement therapy.

Study Type

OBSERVATIONAL

Conditions

Breast Cancer

Interventions

Fine needle aspirationPROCEDURE

Fine needle aspiration

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * postmenopausal women on or off hormone replacement therapy * at high risk of developing breast cancer determined by family or personal history * postmenopausal women not on hormone replacement therapy for at minimum six months prior to corresponding aspiration * willing to participate in companion protocol (KUMC HSC#4601) for random periareolar fine needle aspiration (RPFNA) for correlational studies Exclusion Criteria: * women who have been on raloxifene, tamoxifen, letrozole, anastrozole or exemestane within the six months prior to RPFNA.

Locations (1)

University of Kansas Medical Center

Kansas City, Kansas, United States

Outcomes

Primary Outcomes

Correlation of SNP patterns with cytlomorphology of breast fine needle aspirates.

develoment of algorithm for prediction of risk of developing breast cancer.

Time frame: ongoing

Data from ClinicalTrials.gov

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