A Trial of MitoQ for the Treatment of People With Parkinson's Disease

Inclusion Criteria: 1. Informed consent 2. 30 yrs or older 3. Diagnosis of PD (2 or more of bradykinesia; rest tremor, rigidity) 4. Adequate contraceptive measures (females) Exclusion Criteria: 1. Malignancy within last 2 years 2. Pregnancy \& breast-feeding 3. Treatment with any anti-PD drugs within 30 days of enrolment 4. Prior treatment with anti-PD medication exceeding 42 days in total 5. Medication-induced PD/PD not of idiopathic origin 6. CoQ10/idebenone doses of 300mg/day or higher within 120 days, \>25mg/day within 7 days of enrolment 7. Methylphenidate HCl, neuroleptics, reserpine, amphetamines, selegeline or MAOIs within 6 months of enrolment 8. CNS medications at unstable doses within 60 days of enrolment 9. Dietary supplements \> 5 x RDI 10. Hypersensitivity to CoQ10, idebenone or any components of the study drug 11. Unable to swallow 12. Diseases with features of PD 13. Seizure(s) within 12 months prior to enrolment 14. UPDRS tremor score of 4 15. Hamilton Depression Rating Scale score \> 10 16. History of stroke 17. Requirement for dopaminergic drugs 18. Modified Hoehn \& Yahr score \> 2.5 19. History of brain surgery for Parkinson's disease 20. History of structural brain disease / congenital brain abnormality 21. History of ECT 22. Any other clinically significant medical or psychiatric condition or lab abnormality 23. Enrolment in any other pharmacological study within 30 days of enrolment