Timing of Prophylactic Antibiotics for Cesarean Sections

Medical University of South Carolina350 enrolled

Overview

This is a randomized, double-blinded placebo controlled trial of cefazolin timing before cesarean section fo infection prophylaxis. Subjects are randomized to cefazolin either 30 minutes prior to skin incision or at time of cord-clamping. Primary outcome is infectious morbidity including wound infections and endometritis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

350

Conditions

Endometritis Wound Infection

Interventions

CefazolinDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Pregnant 24-43 weeks gestation \> 18 years old Requiring cesarean section - Exclusion Criteria: Receiving antibiotics \< 18 years old Allergy to cefazolin \-

Locations (1)

Medical University of South Carolina

Charleston, South Carolina, United States

Outcomes

Primary Outcomes

Combined infectious morbidity - endometritis + wound infection

Secondary Outcomes

Neonatal sepsis

Allergic reactions

Data from ClinicalTrials.gov

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