Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism

Tufts University

Overview

The two purposes of this study are 1. to determine what effect the chronic and moderate/heavy drinking of alcoholic beverages has 1. on the blood level of bupropion and chlorzoxazone and their major breakdown products in the blood and 2. on the stimulant effect of bupropion and 2. to determine what effect a normal and common (25% frequency) genetic variation of a specific liver enzyme (that breaks down bupropion) has 1. on the blood levels of bupropion and its major breakdown products in the blood and 2. on the stimulant effect of bupropion. Two groups of volunteers will be recruited for this study: 1. volunteers who drink moderate to heavy amounts of alcohol frequently and 2. volunteers who usually do not drink alcohol. Volunteers will NOT be asked to change their drinking (or nondrinking) habits during the study.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Alcohol Drinking Depression Smoking Cessation Attention Deficit Disorder

Interventions

Trial Withdrawn 1OTHER

Trial Withdrawn 1

Trial Withdrawn 2OTHER

Trial Withdrawn 2

Eligibility

Sex: ALLMin age: 21 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adults who are 21 - 55 years of age. * Either 1) Moderate-to-heavy drinkers who drink on average more than 14 but less than 28 drinks per week; OR 2) adults who normally abstain from drinking alcohol. Exclusion Criteria: * Participants who are currently taking prescription medications (including oral contraceptives) * Pregnancy * Body mass index (BMI) greater than 30 * History of seizures or eating disorders

Locations (1)

Tufts University School of Medicine

Boston, Massachusetts, United States

Data from ClinicalTrials.gov

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