Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal

Inclusion Criteria: * Imminent vitrectomy to repair macular holes or puckers * Ability to be screened for eligibility and begin dosing 7-10 days in advance of the surgery * Best corrected ETDRS visual acuity equivalent to Snellen 20/400 or better in the surgical eye and 20/100 or better in the fellow eye Exclusion Criteria: * Artificial lens or no lens in the surgical eye * Cataract (greater than slight opacity or thickness) in the surgical eye * Any other retinal abnormality which may be vision-threatening * Serious heart, kidney, or liver disease * Recent ophthalmic surgery (within 6 months) or ocular infection (within 30 days) * Poorly controlled diabetes or unstable glaucoma