Thai Prophylactic HIV Vaccine Phase I Study

Inclusion Criteria: * Healthy volunteers, as judged by the screening physician based on medical history, physical examination and laboratory results * 18 - 55 years of age, inclusive * Laboratory blood values within clinically acceptable range * Women of reproductive potential must have a negative urine beta-human chorionic gonadotropin (B-HCG) pregnancy test at both the screening and baseline visits * Agreement to employ barrier contraception for 4 weeks preceding entry and for the whole duration of the study (52 weeks) * Agreement to undertake HIV testing and to receive results * Provision of written informed consent approved by the Institutional Ethics Committee (IEC). Exclusion Criteria: * HIV positive * HBsAg or HCV positive * Identifiable risk behaviour for HIV infection, defined as any one of the following: * sexual partners of HIV positive people * individuals reporting unprotected intercourse with a partner of unknown HIV status, if that partner is reported to be at higher risk for HIV infection ("higher risk of HIV infection" is defined as individuals reporting unprotected anal intercourse (UAI), unprotected intercourse with sex workers and/or sharing injecting equipment within the 12 months preceding trial entry * men reporting any UAI with male partners of unknown status in the 12 months preceding entry to the study * individuals who in the 12 months preceding entry to the study have been diagnosed with a new sexually transmissible infection (STI) that may have been acquired through anal or vaginal intercourse (receptive or insertive) * individuals reporting sharing of injecting equipment in the last 12 months * Recipients of prior HIV candidate vaccines in a previous HIV vaccine trial (does not apply to volunteers who received placebo or adjuvant in such a trial) * Recipients of live attenuated vaccines within 60 days prior to entering the study. Whole killed, toxoid or sub-unit vaccines e.g. influenza, pneumococcus, tetanus, hepatitis B are not exclusionary when given at least 4 weeks prior to the scheduled experimental HIV vaccines * Known or suspected hypersensitivity to egg products or a known history of anaphylaxis or any other serious adverse reactions to any vaccinations * History of serious allergic reactions requiring hospitalisation or emergency medical care (e.g. Steven-Johnson's syndrome, bronchospasm or hypotension) to any substance * Clinically significant intercurrent illness or a history of clinically significant illness requiring immunomodulatory (including corticosteroids) or cytotoxic treatment (e.g. cancer) or any significant disease conditions that in the opinion of the Principal Investigator precludes the individual from participating in the study * Recipients of blood products or immunoglobulins within 6 months prior to entering the study * Recipients of experimental or investigational agents within 30 days prior to entering the study * Recreational and/or therapeutic drug-use that, in the opinion of the Principal Investigator, might compromise the volunteer's participation in any way * Medical or psychiatric condition or occupational responsibilities that may preclude compliance with the protocol * Pregnant or lactating women, or women planning to become pregnant during the trial.