This study is evaluating the feasibility of using helical tomotherapy to deliver IMRT in post-hysterectomy endometrial cancer patients receiving adjuvant radiotherapy.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
65
Washington University School of Medicine
St Louis, Missouri, United States
The study will evaluate the feasibility of using helical tomotherapy to deliver IMRT in post-hysterectomy endometrial cancer patients receiving adjuvant radiotherapy.
The study will be deemed infeasible if greater than 10% of patients experience one of the following: * Patient cannot be given the treatment because her anatomy is such that a dosimetrically satisfactory treatment plan cannot be devised for her. * The patient experiences any grade 4 acute toxicity judged to be related to her external radiation treatment. * Within 1 year of the start of radiation therapy, the patient develops any grade 4 late toxicity judged to be related to her external radiation treatment. * Within 1 year of the start of radiation therapy, the patient develops any in-field pelvic recurrence. * Within 1 year of the start of radiation therapy, the patient dies from causes judged to be related to her treatment.
Time frame: 1 year from the start of radiation therapy.
Evaluate incidence of early toxicities
Time frame: 30 days after last day of radiation therapy
Evaluate incidence of late toxicities
Time frame: 1 year from the start of radiation therapy
Evaluate local, regional, and distant recurrence rates
Time frame: 5 years from start of radiation therapy
Evaluate 5-year disease-free and 5-year overall survival rates
Time frame: 5 years from start of radiation therapy
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.