Hypertension Study: Multinational Torasemide Trial in Mild to Moderate Hypertension.

Inclusion Criteria: 1. Aged from 18 to 75, inclusive. 2. Ambulatory patients diagnosed with mild or moderate arterial hypertension complying with the following requirements: 1. Patients diagnosed "de novo". 2. Patients with prior anti-hypertensive treatment in monotherapy who do not respond to the treatment and, in the investigator's opinion, could benefit from diuretic treatment in monotherapy. 3. Patients with prior anti-hypertensive treatment in monotherapy who do not tolerate the current treatment and, in the investigator's opinion, could benefit from diuretic treatment in monotherapy. Patients with prior treatment must be able to interrupt their present treatment for a period of up to 3 months. (Mild or moderate hypertension defined by blood pressure levels: Systolic blood pressure from 140-179 mm Hg and diastolic blood pressure from 90-109 mm Hg) (2003 European Society of Hypertension-European Society of Cardiology guidelines for management of arterial hypertension) (3) 3. Capable of understanding the nature of the trial. 4. Providing their informed consent in writing. Exclusion Criteria: 1. Pregnant or breastfeeding women and women of fertile age who are not using a safe contraceptive method or do not intend to use one during the trial. Safe contraceptive methods are oral or parenteral contraceptive treatments or barrier methods: masculine or feminine condom, diaphragm and/or IUD. 2. Severe arterial hypertension (systolic blood pressure of 180 mmHg or above and diastolic blood pressure of 110 mmHg or above). 3. Known or suspected secondary arterial hypertension. 4. History of known hypersensitivity to the compound under study or to sulfonylureas. 5. History of repeated and documented hypertensive crises. 6. NYHA grade II to IV congestive heart failure. 7. Severe cardiac arrhythmia (sustained ventricular tachycardia, auricular fibrillation, auricular flutter, bradycardia under 45 beats per minute). 8. Unstable angina pectoris. 9. Acute myocardial infarct in the last 6 months. 10. Liver failure defined by the following analytical parameters: - SGPT (ALT) or SGOT (AST) over twice the upper normal limit. 11. Chronic kidney failure defined by the following analytical parameters: Serum creatinine over 2.3 mg/dl (or 203 mol/L). 12. Patients with insulin-dependent diabetes and patients with non-insulin dependent diabetes. 13. Cerebrovascular accident in the last 6 months. 14. Contraindications in the data obtained during the selection process in the physical examination, haematology, biochemistry, urine analysis and 12-lead ECG, in the investigator's opinion. 15. Simultaneous participation in another clinical trial or treatment with any investigational drug within the 30 days prior to signing the informed consent form. 16. Lactose intolerance. 17. Concomitant treatment with lithium. 18. Patients requiring chronic treatment (treatment \> 7 days) with non-steroidal anti-inflammatory drugs, including aspirin. 19. Patients with concomitant treatment with aminoglycoside antibiotics, etacrynic acid. 20. Chronic administration of any medication affecting blood pressure. 21. Patients in treatment with group 1a, 1b or 2 anti-arrhythmic drugs. 22. History of drug or alcohol addiction within the 6 months prior to the start of the trial. 23. Any clinical circumstance or condition which, in the investigator's opinion, could affect the possibility of completing the protocol and the administration of Torasemide. 24. Obesity with a body mass index (BMI) of over 40 kg/m2. 25. Patients who do not respond to diuretic treatment in monotherapy. 26. Patients with prior anti-hypertensive treatment in monotherapy who are candidates for anti-hypertensive treatment in polytherapy.