Exercise in Improving Mobility and Reducing Fatigue and/or Weakness in Older Cancer Survivors

University of Utah49 enrolled

Overview

RATIONALE: Exercise may help improve mobility and relieve fatigue and/or weakness in cancer survivors. It is not yet known whether exercise is more effective than standard therapy in improving mobility and reducing fatigue and/or weakness in older cancer survivors. PURPOSE: This randomized clinical trial is studying exercise to see how well it works compared to standard therapy in improving mobility and reducing fatigue and/or weakness in older cancer survivors.

OBJECTIVES: * Compare the perception of, and the patterns of change in fatigue, weakness, physical activity level, and functional status in elderly cancer survivors who undergo Resistance Exercise via Negative-Eccentric Work (RENEW) vs standard care. * Compare changes in muscle structure, function (strength + power production and metabolic function) and mobility. * Evaluate the patient's adherence to and satisfaction with the RENEW intervention. OUTLINE: This is a prospective, randomized, controlled, longitudinal study. Patients are randomized to 1 of 2 intervention arms. * Arm I: Patients undergo resistance exercise via negative-eccentric work (RENEW), using a special seated stationary leg exercise machine, 3 times a week for up to 12 weeks. Exercise exertion and duration is gradually increased weekly for the first 4-5 weeks of RENEW. * Arm II: Patients receive standard care. In both arms, fatigue, weakness, physical activity, functional status, muscle structure and function, and mobility are assessed at baseline and then at 12 weeks after completion of study intervention. Fatigue and weakness are also assessed weekly during study intervention. Patients in arm I also undergo isometric strength assessment weekly during RENEW and assessment of adherence to and satisfaction with RENEW at 12 weeks after completion of RENEW. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Interventions

exercise interventionBEHAVIORAL

12 weeks of 3x/week training on a recumbent eccentric stepper

complementary or alternative medicine procedurePROCEDURE

12 weeks of 3x/week training on the eccentron

fatigue assessment and managementPROCEDURE

The visual analog scale will be used to assess muscle soreness from the previous exercise session

physical therapyPROCEDURE

12 weeks of 3x/week training on the eccentron

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Survivor of breast, prostate, colon, lung, lymphoma, ovarian, bladder, or esophageal cancer with no evidence of disease * At least moderate levels of fatigue and/or weakness * Impaired mobility but ambulatory and medically able to participate in an exercise regimen * No impaired knee flexion, defined as \< 90º PATIENT CHARACTERISTICS: * Folstein Mini-Mental Status Examination score ≥ 23 * No extreme claustrophobia * No diagnosed chronic fatigue syndrome/disorder * No neurological impairments, including the following: * Central nervous system disorder (e.g., multiple sclerosis or Parkinson's disease) * Neurological insult (cerebrovascular attack) that manifests in a mobility disorder * No myopathic disease (e.g., focal myopathy) that effects skeletal muscle structure/function * No rheumatological disease that has an effect on muscle and/or mobility (e.g., polymyalgia rheumatica) PRIOR CONCURRENT THERAPY: * More than 6 months since prior regular aerobic or resistance exercise * Regular exercise defined as 2-3 times per week * At least 6 months since prior cancer treatment (surgery, radiation, and/or chemotherapy ) * No concurrent cancer-related treatment other than hormonal therapy

Outcomes

Primary Outcomes

Patient perception and pattern of change

To explore the participant's perception and pattern of change in fatigue, weakness, physical activity level and functional status

Time frame: 3 months of training followed by 6 and 12 months of no formal training

Secondary Outcomes

Structural and function changes

To explore whether changes in muscle structure and function (strength and power production and metabolic function) and mobility occur following twelve weeks of training with RENEW