Banding Versus Propranolol for Primary Prophylaxis of Variceal Bleeding

Phase 3TerminatedNCT00337740

University of Padova120 enrolled

Overview

Whether beta-blockers or banding is the best therapy for primary prophylaxis of variceal bleeding is subject to debate. A randomized comparison between the two treatments was performed in candidates for liver transplantation. Patients with Child B and C cirrhosis with high risk varices and no previous variceal bleeding are randomized to propranolol or variceal bleeding. Primary end point is variceal bleeding

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

120

Conditions

Liver Cirrhosis Esophageal Varices

Interventions

endoscopic variceal bandingPROCEDURE

propranololDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * liver cirrhosis * child pugh\>=B7 * studied for transplantation * age between 18 an 65 ys * no previous bleeding from varices * signed informed consent Exclusion Criteria: * esophageal varices less than F2 blue * gastric varices * previous variceal surgical or radiological or endoscopical treatment * hepatocarcinoma * portal vein thrombosis * severe heart, respiratory or renal failure * contraindications to betablockers * treatment with nitrates, calcium antagonist or anti-arhythmic drugs that can not be suspended * Pregnancy * neoplasias * non cooperation

Locations (1)

Clinica Chirurgica 1^, Policlinico Universitario, Via Giustiniani 2

Padua, Italy

Outcomes

Primary Outcomes

variceal bleeding

Data from ClinicalTrials.gov

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