Observational Study of Iron Metabolism in Anemia in ICU and Post-Operative Patients

Assistance Publique - Hôpitaux de Paris153 enrolled

Overview

Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation.

Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation. The latter is known to interfere with iron metabolism, inducing iron storage instead of using it for hemoglobin synthesis. The discover of a new regulatory hormone of iron metabolism, hepcidin, may help us to better understand the link between inflammation and iron functional deficit. The aim of our study is to observe the variation of usual iron metabolism biological markers and of hepcidin, in order to define the better marker of iron loss in these clinical situations.

Study Type

OBSERVATIONAL

Enrollment

153

Conditions

Anemia Intensive Care Cardiac Surgery

Eligibility

Sex: ALLMin age: 20 YearsMax age: 88 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Anemia (haemoglobin \< 10 g/dL) * Hospitalization in ICU for an expected duration of 7 days or more * Or, day one post cardiac surgery Exclusion Criteria: * Chronic anemia (Hb \< 9 g/dL for more than one month before hospitalization) * Iron metabolism disease

Locations (1)

APHP, hopital Bichat

Paris, France

Outcomes

Primary Outcomes

Functional iron deficiency

Time frame: during the study

Secondary Outcomes

fatigue assessed by the MFI20 score for cardiac surgery patients

Time frame: at one day,at seven days and at 28 days

Data from ClinicalTrials.gov

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