24 week, single center, prospective, randomized, double-blind treatment study of valsartan (80 mg/bid, increased to 160 mg/bid) or placebo in addition to other general medical therapy in patients with persistent atrial fibrillation (AF) undergoing electrical cardioversion to restore normal sinus rhythm (SR).
To evaluate the efficacy of valsartan, added to standard AF therapy, to maintain sinus rhythm and extend the interval to first AF recurrence after cardioversion.Evaluate the efficacy of valsartan, begun prior to cardioversion, on the difficulty (number and total energy of CV attempts), the net rate of cardioversion (to SR for \>10 minutes), and early AF recurrence rate (within 24 hours)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
200
McKay Dee Hospital
Ogden, Utah, United States
LDS Hospital
Salt Lake City, Utah, United States
Dixie Regional Medical Center
St. George, Utah, United States
Time to first AF recurrence on valsartan vs. placebo (time-to-event analysis, log-rank test)
Number of CV attempts in order to restore SR in valsartan vs. placebo
Total electrical energy expended in 2 groups to achieve SR
Rate of early AF recurrence (within 24 hours) in the 2 groups after achieving SR
Net rate of NSR in the 2 groups at 24 hours.
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