PK and PD Responses to Oral L-Citrulline in Patients With Sickle Cell Disease

Inclusion Criteria: 1. Male or female, 10 years of age or older on the day of dosing, and generally healthy as determined by medical history, physical examination, and laboratory test values 2. Diagnosis of sickle cell anemia (Hb SS) 3. For female of child-bearing potential, a negative serum pregnancy test and using an adequate method of contraception 4. Has signed and received a copy of the written informed consent form approved by the investigator's Institutional Review Board (IRB), understands the purposes and risks of the study and agrees to follow the restrictions and schedule of procedures as defined by this protocol Exclusion Criteria: 1. History of sickle-cell-related pain crisis within two weeks of study 2. Pregnant or breast feeding 3. Transfusion within last 90 days 4. Creatinine \>1.5 X upper limit of normal 5. SGPT \> 2 X upper limit of normal 6. History of allergic reaction to arginine or citrulline product 7. Requires chronic medication other than study drug that cannot be discontinued during the study period 8. Unable to take or tolerate oral medications 9. Unreliable venous access 10. Noncompliant with regular care 11. Participation in an investigational drug or medical device study within previous 30 days 12. In the opinion of the investigator is not a good candidate for participation in the study