Bupropion Treatment for Youth Smoking Cessation

Inclusion Criteria: * 14 to 17 years of age * Smoked at least 6 cigarettes per day * Exhaled CO greater than or equal to 10 ppm * Made at least two previous quit attempts * Weighed at least 90 pounds * Able to read English at least the 6th grade level * Motivated to quit smoking as evidenced by willingness to commit to study protocol requirements for the duration of the study * provided active parental consent and youth assent Exclusion Criteria: * Current use of tobacco products other than cigarettes, unless willing to abstain from these products for the study duration * Current use of other treatments for smoking cessation * History or current diagnosis of panic disorder, psychosis, bipolar disorder, or eating disorder * History of abuse or dependence on alcohol or other recreational or prescription drugs in the three months preceding the study * Current evidence of clinical depression or Attention Deficit/Hyperactivity Disorder * Use of any psychoactive drug and/or any type of antidepressant with in four weeks of the treatment phase of the study * Predisposition to seizure or tic disorders or a personal history of a seizure disorder, family history of seizure disorders, or treatment with medication or therapies that increase the risk of seizures * Significant history of or current clinical evidence of cardiovascular disease * (Females)Pregnancy (urine pregnancy test), lactation or, if sexually active, unwillingness to use a medically acceptable form of contraception for the duration of the study * Only one member of a household was allowed to participate in the study concurrently.