Acute Effect of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

Regional Hospital Holstebro20 enrolled

Overview

We wanted to test the acute effect of HMG-CoA reductase inhibition (atorvastatin) on renal hemodynamics, renal tubular function and vasoactive hormones on healthy subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

HMG-CoA reductase inhibition (atorvastatin)DRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Both men and women * Age: Between 20-50 * BMI\<30 Exclusion Criteria: * Clinical signs or history of disease of heart, lungs, kidneys or endocrine organs. * Abnormal lab. tests( haemoglobin, pl. sodium, pl. potassium, pl.creatinine, pl.bilirubin, pl.ALAT, pl. cholesterol, blood glucose) * Albuminuria or glucosuria * Cancer * Art. hypertension * Alcohol abuse * Medical treatment, except oral contraceptives * Pregnancy or breast feeding * Blood donation less than 1 month before study

Locations (1)

Medical Research

Holstebro, Denmark

Outcomes

Primary Outcomes

GFR

RPF

FEna

FELi

CLna

CLli

Data from ClinicalTrials.gov

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