The aim of the study is to test the following hypotheses: * that the function and/or regulation of AQP2 and/or ENaC in the principal cells is abnormal in essential hypertension. * if an abnormal function of the principal cells is present in essential hypertension, this will become more pronounced at high and low sodium intake.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
DOUBLE
Enrollment
50
250-350 mmol
25-35 mmol
Department of Medical Research, Holstebro Hospital
Holstebro, Denmark
u-AQP-2
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
fractional sodium excretion
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
p-vasopressin
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
p-aldosterone
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
u-p-AQP-2
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
u-ENaC(alfa,beta,gamma)
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
CH2O
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
u-cAMP
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
uPGE2
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
GFR
Time frame: Before and after hypertonic saline infusion after 4 days on high and low sodium diet, respectively.
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