A Multi-Center Trial of Botox for Severe Urge Urinary Incontinence

Inclusion Criteria: * Female subjects 21-90 years of age * subjects has urinary incontinence on 3 day bladder diary * subject has severe incontinence * urine dipstick or urine culture negative for urinary tract infection * cystometrogram without stress urinary leakage * must have failed at least one anti-cholinergic medication * negative urine pregnancy test on day of administration of study medication Exclusion Criteria: * history of carcinoma of the bladder * presence of foreign body in the bladder, cystitis or other correctable etiology for Urge Urinary Incontinance * gross fecal incontinence * known allergy to sulfa or ciprofloxacin or to lidocaine * any medical condition that may put the subject at increased risk with exposure to Botox * females who are pregnant, breast-feeding, or planning a pregnancy during the study or who are of child-bearing potential * known allergy to any of the components in the study medication * prior documented resistance to Botox * evidence of recent alcohol or drug abuse * concurrent participation in another investigational drug or device study within 30 days