Iloprost for Prevention of Contrast-Mediated Nephropathy in High-Risk Patients Undergoing Coronary Angiography and/or Intervention

Inclusion Criteria: * Patients undergoing clinically driven, non-emergent coronary angiography or intervention in our institution were eligible for inclusion if their serum creatinine concentration was ≥1.4 mg/dl (124 μmol/l) and/or their creatinine clearance was \<60 ml/min on their most recent sample drawn within 1 month of the planned procedure Exclusion Criteria: * Circulatory shock for any reason, systolic blood pressure \<95 mm Hg * Known acute renal failure * End-stage renal disease requiring dialysis * Intravascular administration of a contrast medium within the previous 10 days * Anticipated re-administration of contrast medium within the following 6 days * Inability to administer intravenous hydration at least 4 h before the procedure or study medication at least 30 min before the procedure * Primary intervention for acute infarction with ST elevation * A procedure performed within 2 h of acute hospital admission