Clinical Study of Capecitabine, Oxaliplatin and Bevacizumab in Colorectal Cancer

Inclusion Criteria: * Adult patients 20-74 years of age * Histologically confirmed colorectal cancer * Metastatic and/or locally advanced colorectal cancer not previously treated with chemotherapy for metastatic disease * At least one measurable lesion according to RECIST Exclusion Criteria: * Evidence of clinically detectable ascites at study treatment start * Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study treatment start, or anticipation of the need for major surgical procedure during the course of the study; fine needle aspiration within 7 days prior to study treatment start. * Evidence of bleeding diathesis or coagulopathy * Serious, non-healing wound, ulcer, or bone fracture * Chronic, daily aspirin (\> 325 mg/day), anticoagulants, or other medications known to predispose to gastrointestinal ulceration