RATIONALE: Dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
PURPOSE: This phase I trial is studying the side effects of dasatinib in treating patients with chronic myelogenous leukemia or acute lymphoblastic leukemia.
OBJECTIVES:
Primary
* Determine the long-term safety and tolerability of dasatinib in patients with Philadelphia chromosome-positive chronic myelogenous leukemia or acute lymphoblastic leukemia resistant or intolerant to imatinib mesylate.
Secondary
* Describe any hematologic or cytogenetic response in patients treated with this drug.
* Determine the duration of hematologic and cytogenetic response in patients using this drug during trial UCLA-0303035.
* Determine the progression-free survival and overall survival of patients treated with this drug.
OUTLINE: This is an open-label, roll-over study of protocol UCLA-0303035.
Patients receive oral dasatinib once or twice daily for 5, 6, or 7 days. Treatment repeats every 7 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed periodically for 5 years.
PROJECTED ACCRUAL: A total of 54 patients will be accrued for this study.
DISEASE CHARACTERISTICS:
* Diagnosis of one of the following hematologic malignancies:
* Chronic phase chronic myelogenous leukemia (CML)
* In complete hematologic response after treatment on protocol UCLA-0303035, as indicated by the following criteria:
* WBC ≤ upper limit of normal (ULN)
* Platelet count \< 450,000/mm\^3
* No blasts or promyelocytes in peripheral blood
* Less than 5% myelocytes plus metamyelocytes in peripheral blood
* Peripheral blood basophils ≤ ULN
* No extramedullary involvement (including no hepatomegaly or splenomegaly)
* Response lasting ≥ 4 weeks after first documentation
* Accelerated or blastic phase CML or acute lymphoblastic leukemia
* In major hematologic response\* after treatment on protocol UCLA-0303035, defined as 1 of the following:
* In complete hematologic response\*, as indicated by the following criteria:
* WBC ≤ ULN
* Absolute neutrophil count ≥ 1,000/mm\^3
* Platelet count ≥ 100,000/mm\^3
* No blasts or promyelocytes in peripheral blood
* Bone marrow blasts ≤ 5%
* Less than 5% myelocytes plus metamyelocytes in peripheral blood
* Peripheral blood basophils ≤ ULN
* No extramedullary involvement (including no hepatomegaly or splenomegaly)
* No evidence of leukemia, as indicated by the following criteria:
* WBC ≤ ULN
* No blasts or promyelocytes in the peripheral blood
* Bone marrow blasts ≤ 5%
* Less than 5% myelocytes plus metamyelocytes in peripheral blood
* Peripheral blood basophils ≤ ULN
* No extramedullary involvement (including no hepatomegaly or splenomegaly)
* Absolute neutrophil count ≥ 500/mm\^3 and \< 1,000/mm\^3 AND platelet count ≥ 20,000/mm\^3 and \< 100,000/mm\^3
* In minor hematologic response\* after treatment on protocol UCLA-0303035, as indicated by the following criteria:
* Less than 15% in bone marrow and \< 15% in peripheral blood
* Less than 30% blasts plus promyelocytes in bone marrow and \< 30% blasts plus promyelocytes in peripheral blood
* Less than 20% basophils in peripheral blood
* No extramedullary disease other than spleen and liver NOTE: \*Response confirmed after ≥ 4 weeks allowed provided there is no concurrent anagrelide or hydroxyurea during this time
* Philadelphia chromosome-positive (Ph+) disease
* Resistant or intolerant to prior imatinib mesylate
* Received and benefitted from ≥ 3 months of prior therapy with dasatinib on protocol UCLA-0303035
PATIENT CHARACTERISTICS:
* ECOG performance status 0-2
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception during and for 12 weeks after completion of study treatment
* No serious uncontrolled medical disorder
* No active infection that would preclude study participation
* No uncontrolled angina within the past 3 months
* No diagnosed or suspected congenital long QT syndrome
* No history of clinically significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, or torsades de pointes)
* QTc ≤ 450 msec on electrocardiogram
* No uncontrolled hypertension
* No dementia or altered mental status the would prohibit the understanding or rendering of informed consent
* No history of the following significant bleeding disorders unrelated to CML:
* Diagnosed congenital bleeding disorders (e.g., von Willebrand's disease)
* Diagnosed acquired bleeding disorder in the past year (e.g., acquired antifactor VIII antibodies)
* Not involuntarily incarcerated for either psychiatric or physical (e.g., infectious disease) illness
* No patients who are imprisoned
* No clinical adverse event, laboratory abnormality, or intercurrent illness that may preclude study treatment, in the opinion of the investigator
* Bilirubin \< 1.5 mg/dL
* ALT and AST \< 2 times upper limit of normal (ULN)
* Creatinine \< 1.5 times ULN
PRIOR CONCURRENT THERAPY:
* See Disease Characteristics
* No concurrent use of the following drugs that may confer risk of torsades de pointes:
* Quinidine
* Procainamide
* Disopyramide
* Amiodarone
* Sotalol
* Ibutilide
* Dofetilide
* Erythromycin
* Clarithromycin
* Chlorpromazine
* Haloperidol
* Mesoridazine
* Thioridazine
* Pimozide
* Cisapride
* Bepridil
* Droperidol
* Methadone
* Arsenic
* Chloroquine
* Domperidone
* Halofantrine
* Levomethadyl
* Pentamidine
* Sparfloxacin
* Lidoflazine
* No other concurrent treatment for CML except for hydroxyurea for a 2-week duration
* No concurrent medications that inhibit platelet function (e.g., aspirin, dipyridamole, epoprostenol, eptifibatide, clopidogrel, cilostazol, abciximab, ticlopidine, or any nonsteroidal anti-inflammatory drug)\* except for hydroxyurea or anagrelide
* No concurrent anticoagulants (e.g., warfarin or heparin/low molecular weight heparin \[e.g., danaparoid, dalteparin, tinzaparin, or enoxaparin\]) except as prophylaxis for catheter thrombosis and/or heparin flushes for IV lines\* NOTE: \*Allowed if received previously on UCLA-0303035