Adalimumab in Uveitis Refractory to Conventional Therapy (ADUR Trial)

Inclusion Criteria: * Male and female patients age 18 and older * Subjects must meet the criteria for non-infectious uveitis according to the definition of the SUN working group * Uveitis must have first been diagnosed at least 6 months ago * Persistence of active disease ( \> 2 flares within 6 months) or progressive deterioration of vision (\< 0,6) within the last 3 months despite immunosuppressive therapy requiring corticosteroids ≥ 7,5 mg prednisone * Women of childbearing potential have to practice a reliable birth control method throughout the study and until five months after the last administration of Adalimumab * Ability to comprehend and willing to give informed consent for participation in the study * Able and willing to self-administer sc injections or assistance of a suitable person to administer sc injections * Negative PPD skin test or serological testing according to official German recommendations for tuberculosis testing AND chest X-ray within the last three month. Treatment of latent TB with INH must be started 4 weeks prior to administration of first dose of study drug. Exclusion Criteria: * Participation in another clinical trial and/or observation period of competing trials * Treatment with infliximab within the last 2 months or with etanercept within the last 3 weeks * Patients with only intermediary uveitis or optic neuritis multiple sclerosis * Patients with uveitis caused by infection * Patients with optic atrophy, macular scar, cataract, amblyopia or corneal scars * Patients with recurrent episodes of uveitis, but long intermittent phases of complete remissions without therapy * Patients possibly demanding vitrectomy or cataract surgery within the time of clinical trial * Pregnant and nursing women or women planning a pregnancy within 5 months * Persistent or recurrent infections or severe infections requiring hospitalization with iv antibiotics within 30 days, or oral antibiotics within 14 days prior to enrollment * Known opportunistic infection (such as herpes zoster) during the last 2 months * Live vaccination during the last 30 days * History of tuberculosis; histoplasmosis or listeriosis * Known HIV infection, active hepatitis B or C * Comorbidities: uncontrolled diabetes, unstable ischemic heart disease, congestive heart failure (NYHA III, IV), active inflammatory bowl disease, recent stroke (within three months), chronic leg ulcer and similar conditions which would put the subject at risk by participation in the trial * Previous diagnosis of signs of central nervous system demyelinating diseases * History of cancer or lymphoproliferative disease other than a successfully and completely treated squamous cell or basal cell carcinoma of the skin or cervical dysplasia, with no recurrence within the last two years * Hemoglobin \< 10 g/dl, white blood cell count \< 3.0x109/l, platelet count \< 100x109/l, creatinine level \>1.5 mg/dl, liver enzymes \> 1.5 times above normal or alkaline phosphatase \>3 times above normal * Clinical examination showing significant abnormalities of clinical relevance * Current evidence of significant abuse of drugs * Psychiatric disease/social situations that would limit compliance with study requirements