Spatial Neglect and Bias in Near and Far Space

Kessler Foundation950 enrolled

Overview

The purpose of this research study is to learn how people distribute their visual attention when looking at objects nearby versus far away, and why vision may become distracted at near versus far distances.

Visual distraction is a problem that more often occurs people who have suffered strokes than in the general population. Problems of visual attention generally appear immediately following a stroke, and may impair driving and other functions. While it is thought that there is a natural course of improvement over time, little is known about how this improvement occurs. Some studies suggest that recovery is only partial, meaning certain aspects of visual attention may improve while other aspects remain but escape notice. The purpose of this study is to examine the effect of stroke on a person's visual attention when looking at objects nearby versus far away, and to learn why a person's visual attention may become more distracted at near versus far distances. The purpose of this study is also to understand how modeled interventions, such as eye patching or prism goggles, affect impairment measures of visual attention. After an initial screening (including attention, thinking, memory, and visual judgment tests), participants will be given a neurological examination. Participants may be asked to perform visual tasks while wearing an eye patch or prism goggles. Next, they will be asked to perform a line bisection task by looking at lines on a video screen either at close or far distances and, using a laser pointer, marking the center of the lines as they appear on-screen. Participants may be asked to perform other, similar visual tasks as well. Duration of the study for participants varies, ranging from 1 or 2 sessions totaling approximately 2 hours to multiple sessions spanning a year. Research from this study may help researchers better understand problems associated with stroke and may lead to therapies designed to promote improved visual attention.

Study Type

OBSERVATIONAL

Enrollment

950

Conditions

Stroke

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The subject has a history of stroke. * The subject is 18 to 100 years old. * The subject is able to give Informed consent. * The subject is post-Stroke with left-hemisphere injury and has no spatial neglect (no attentional imbalance). * The subject is post-stroke with right hemisphere damage and has spatial neglect (attentional imbalance). * Healthy subject with no brain injury. * The subject is post stroke and has hemianopia (a "visual field cut"). * The subject is able and willing to comply with the study protocol, including availability for all scheduled clinic visits. Exclusion Criteria: * Subjects with brain tumors, head injury with loss of consciousness, visual disorders other than corrected near or far-sightedness, history of learning disabilities, dementia or Alzheimer's Disease.

Locations (1)

Kessler Foundation, 1199 Pleasant Valley Way

West Orange, New Jersey, United States

Outcomes

Primary Outcomes

Kessler Foundation Neglect Assessment Process

a performance based and behavioral measure for spatial neglect that utilizes and standardizes the administration of the Catherine Bergego Scale (CBS)

Time frame: From 1 or 2 sessions totaling approximately 2 hours to multiple sessions in one year

Secondary Outcomes

Behavior Inattention Test Behavior Inattention Test

Conventional subtest, a set of paper and pencil test for spatial neglect

Time frame: 2 weeks

Barthel Index

A functional independence assessment of daily tasks

Time frame: 2 weeks

Data from ClinicalTrials.gov

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