The purpose of this study is to see if intravenous Vitamin C will decrease the amount of IV fluids needed following burn injury in the first 48 hours.
Adequate fluid resuscitation in burn injured patients to allow adequate renal blood flow has been the hallmark of burn care in the last 50 years. The danger of exceeding the optimal intravenous fluid resuscitation has resulted in severe complications including abdominal compartment syndrome, loss of upper airway control, extremity compartment syndromes and pulmonary edema. Hig dose vitamin C infusion during the first 24 hours of burn resuscitation has been documented to decrease the overall amount of intravenous fluid needed to provide for adequate renal perfusion and hemodynamic stability in multiple animal model studies. High dose vitamin C is thought to decrease postburn microvascular protein and fluid leakage by reducing postburn lipid oxygenation caused by burn injury generated free radicals.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
vitamin C IV during 24 hour period following burn
IV vitamin C
United States Army Institute of Surgical Research
Fort Sam Houston, Texas, United States
Document a significantly lower intravenous fluid requirement per percent total body surface area burn in the High Dose Vitamin C group
Time frame: 72 hours
Document a significantly higher number of mechanical ventilator free days
Time frame: 7 days
Document a significantly lower complication and infection rate in the Vitamin C group
Time frame: 7 days
Document decreased lipid peroxidation by monitoring serum malondialdehyde (MDA) level
Time frame: 72 hours
Document a lower incidence of organ failure
Time frame: 30 days
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