The Effects of Omega-3 Fatty Acids on Metabolic Syndrome

Inclusion Criteria: * Adults with Metabolic Syndrome (meets 3 of the following 5) * Abdominal obesity, waist circumference in men greater than 40 in. \& in women greater than 35 in. * Serum triglycerides greater than or = 150 mg/dL (1.7 mmol/L) * Serum HDL cholesterol less than or = 40 mg/dL in men and less than 50 mg/dL in women * Blood pressure greater than or = 130/85 mmHg or drug treatment for elevated blood pressure * Fasting plasma glucose greater than 100 mg/dL Exclusion Criteria: * Diabetes * Known or documented CHD (including ECG consistent with prior MI), CVA (including TIA), PVD (including symptoms of claudication) * Angina or other chest pain that may indicate CHD * Clinically significant neoplastic, cardiovascular, hepatic, renal, metabolic, endocrine (untreated or unstable), or psychiatric (untreated or unstable) * Known abnormal LFTS greater than 2X ULN * Smoker, illicit drug use, or excessive alcohol use * Medications: Lipid lowering therapy, daily NSAID or greater than 325 mg ASA (PRN use ok), clopidogrel (or equivalent), Coumadin, Omega-3 fatty acid supplement, other investigational drugs within 30 days of study entry, high omega-3 fatty acid content in diet within past three months * Pregnancy or planning pregnancy during the study period * Sensitivity or allergy to fish