This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).
This study will compare four types of treatment involving skills training and incentives for attending sessions or taking study medication. Disulfiram is a widely prescribed deterrent to alcohol use. In addition to weekly cognitive behavioral therapy (CBT), participants will be assigned to one of the following treatments: 1. placebo 2. disulfiram 3. placebo plus incentives for cocaine abstinence and medication compliance (prize CM) 4. disulfiram plus incentives for cocaine abstinence and medication compliance
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
181
250mg per day of Disulfiram plus CBT
Placebo plus CBT
Placebo plus Contingency Management for cocaine abstinence and medication compliance in addition to CBT
APT Foundation
New Haven, Connecticut, United States
Change in Cocaine Use by Self Report
Self-reports of substance use will be documented at each contact via the Substance Use Calendar. Similar to the Form-90 and the Time Line Follow-Back, which have been shown to be reliable and valid instruments for monitoring substance use and other outcomes in longitudinal studies202-204, the Substance Use Calendar allows a flexible, continuous evaluation of substance use on a daily basis.
Time frame: 12 weeks
Change in Cocaine Use by Urine Toxicology Results
We will use the Roche onsite TESTCUP system for detection of cocaine, methamphetamine, THC, benzodiazepenes, and opioids.
Time frame: 12 weeks
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250mg of Disulfiram plus Contingency Management for cocaine abstinence and medication compliance plus CBT.