The purpose of this study is to assess the safety and tolerability of multiple escalating doses of BMS-663513 when given in combination with paclitaxel and carboplatin.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
45
mg/kg, IV, 0.3, 1, 3, 10 mg/kg, q 3 wks, up to 24 weeks
University Of Pennsylvania Medical Center
Philadelphia, Pennsylvania, United States
Magee-Womens Hospital Of Upmc
Pittsburgh, Pennsylvania, United States
University Of Virginia
Charlottesville, Virginia, United States
University Of Washington
Seattle, Washington, United States
To assess the safety and tolerability of multiple ascending doses of BMS-663513 when given in combination with paclitaxel and carboplatin to subjects with advanced malignancies
Time frame: throughout the study
Explore PK and PD associations of BMS-663513 and the effect of BMS-663513 on immune system markers.
Time frame: throughout the study
Describe anti-tumor activity
Time frame: throughout the study
Obtain tissue or ascites for exploratory research
Time frame: throughout the study
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Local Institution
Toronto, Ontario, Canada