Irinotecan and Cisplatin for High Grade Neuroendocrine Carcinoma of the Gastrointestinal Tract

Inclusion Criteria: 1. Histologic diagnosis of high grade (poorly differentiated, small cell) gastrointestinal neuroendocrine carcinoma. 2. High grade neuroendocrine carcinoma of unknown primary site (if a pulmonary primary has been excluded). 3. Metastatic or unresectable disease. 4. Measurable disease. 5. Informed consent. 6. Zubrod performance status of 0 or 1. 7. Adequate bone marrow function (defined as absolute neutrophil count \[ANC\] \>= 1500, platelet count \[PLT\] \>= 100,000 and a hemoglobin \[Hgb\] \>= 10). 8. Adequate hepatic function with a bilirubin of \<= 2.0 mg/dl, and aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT) \<= 2.5 times the upper limits of normal, unless caused by liver metastasis. If caused by metastasis, then should be SGPT and SGOT \<= 5 times the upper limits of normal. 9. Adequate renal function defined as serum creatinine \<= 1.5 mg/dl. 10. Fertile patients and their partners must practice appropriate contraceptive methods while on study. 11. Recovered from recent surgery. One week must have elapsed from the time of a minor surgery and 3 weeks from major surgery. Exclusion Criteria: 1. Patients with prior systemic chemotherapy are ineligible. 2. Other concurrent chemotherapy, immunotherapy, or radiotherapy. 3. Patients with brain metastases are not eligible. Patients with a history of seizures are ineligible. Patients receiving phenytoin, phenobarbital, or other antiepileptic prophylaxis are ineligible. 4. Patients with New York Heart Association (NYHA) Class III or IV heart disease are not eligible as well as those patients with history of angina, myocardial infarction, or congestive heart failure within six months. 5. Pregnant or lactating women. All women of child bearing potential must have a negative pregnancy test prior to entry into the study. All patients of child bearing potential must be advised of the importance of avoiding pregnancy and using appropriate methods of contraception while participating in this investigational trial. 6. Patients with serious intercurrent infections, or nonmalignant medical illnesses that are uncontrolled or whose control may be jeopardized by the complications of this therapy, are ineligible. 7. Patients with psychiatric disorders rendering them incapable of complying with the requirements of the protocol are ineligible. 8. Patients with serum calcium \> 12 mg/dl or symptomatic hypercalcemia under treatment are ineligible. 9. Patients with osseous metastasis as only site of disease. 10. Patients with any concurrent active malignancy other than non-melanoma skin cancers or carcinoma-in-situ of the cervix. Patients with previous malignancies but without evidence of disease for \> 5 years will be allowed to enter the trial. 11. Patients with known Gilbert's syndrome are ineligible.