Total Lymphoid Irradiation (TLI) to Prevent Focal Segmental Glomerulosclerosis (FSGS)Recurrence in the Renal Graft

University of Sao Paulo10 enrolled

Overview

The purpose was study the immunosuppression using total lymphoid irradiation plus Csa, MMF and prednisone pretransplant to prevent focal segmental glomerulosclerosis recurrence in the renal graft

Focal and segmental glomerulosclerosis (FSGS) is resistant to treatment with immunosuppressants and after transplant, 40% of such patients have recurrences in renal allograft. The purpose of this trial was to use Total Lymphoid Irradiation (TLI) plus mycophenolate mofetil (MMF), cyclosporine A (CsA) and prednisone (PRED) to prevent recurrence.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Glomerulosclerosis, Focal

Interventions

Total Lymphoid irradiationPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients (age \> 18 years) * Biopsy-proven primary FSGS * End-stage renal failure at presentation or prior allograft loss due to recurrent FSGS. * Signed the informed consent before entering in the study. Exclusion Criteria: * Age \< or equal 18 years * No biopsy-proven FSGS * Without living donor to perform the transplant * No signed the informed consent

Locations (1)

Hospital das Clinicas - Division of Urology and Radiotherapy - University of Sao Paulo

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Efficacy of immunosuppression using TLI plus CsA, MMF and Pred in prevent recurrence of FSGS after the renal transplant

Secondary Outcomes

Morbidity and mortality ot the treatment

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.