Selection of Antibiotic Resistance by Azithromycin and Clarithromycin in the Oral Flora

Universiteit Antwerpen203 enrolled

Overview

Resistance to antibiotics is a major public-health problem and studies linking antibiotic use and resistance have shown an association not a causal effect. Utilizing the newer macrolides, azithromycin and clarithromycin that are commonly prescribed for respiratory infections, we investigated the direct impact of antibiotic exposure on resistance at the individual level. 203 healthy cohorts were treated with azithromycin, clarithromycin, or a placebo in a randomised, double-blind trial. Pharyngeal swabs were collected pre- (day 0) and post-antibiotic administration (days 8, 14, 28, 42, 180) and proportions of macrolide-resistant streptococci (MRS) were determined at each time-point.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

203

Conditions

Healthy Volunteers

Interventions

Macrolides (azithromycin or clarithromycin)DRUG

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy adults (≥ 18 years of age) * non-pregnant * free of any respiratory tract infection * not having been administered any antibiotic at least in the past three months Exclusion Criteria: * \<18 years of age * pregnant * having a respiratory tract infection * having been administered any antibiotic at least in the past three months

Locations (1)

Depatment of Medical Microbiology, Universiteit Antwerpen

Antwerp, Antwerp, Belgium

Outcomes

Primary Outcomes

Changes in proportions of macrolide-resistant streptococcal (MRS) carriage in the oropharynx

Secondary Outcomes

Variations in the carriage of macrolide-resistance genes due to macrolide exposure.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.