Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term

Nilratan Sircar Medical College932 enrolled

Overview

The purpose of this study is to determine whether induction of labor with vaginal misoprostol application will result in fewer cesarean deliveries than vaginal PGE2 gel application in women with premature rupture of membranes at term.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

932

Conditions

Premature Rupture of Membranes at Term

Interventions

MisoprostolDRUG

Vaginal application of Misoprostol tablets at 4 hrly interval with maximumof five doses

PGE2 gelDRUG

PGE2 gel will be applied in poaterior fornix at six hrly interval with maximum of 2 doses

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Premature rupture of membranes at 37 or more weeks * Single live fetus in cephalic presentation Exclusion Criteria: * Women in labour * Women with contraindication of induction of labour * Women with previous caesarean section or uterine surgery

Locations (1)

Nilratan Sircar Medical College, 138,AJC Bose Road,

Kolkata, West Bengal, India

Outcomes

Primary Outcomes

Caesarean Section rate

Time frame: 48 hours

Secondary Outcomes

Induction delivery time

Time frame: 48 hours

Neonatal & maternal infectious morbidity

Time frame: 14 days following date of delivery

Data from ClinicalTrials.gov

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