Testosterone Replacement in Diabetes With Vascular Disease (Version 2)

Inclusion Criteria: * Male patients greater than 18 years of age * Type 2 Diabetes Mellitus * Serum testosterone less than 11 nmol/L on two consecutive samples taken on different days * Peripheral vascular disease as defined by ABPI less than 0.92 and ischaemic leg pain (claudication or rest pain) or distal complications (non-healing arterial foot ulcer or gangrene * Agreement to maintain antihypertensive and anti-lipid treatments at prior doses during 3 months of study * Ability to give written informed consent after verbal and written explanation in the English Language * Ability to comply with all study requirements Exclusion Criteria: * Current or previous breast cancer * Current or previous prostate cancer * Raised prostate specific antigen or abnormal per rectal examination unless prostate cancer excluded after specialist urology opinion * Severe symptoms of benign prostatic hypertrophy ('prostatism') * Treatment with testosterone in the 3 months prior to the trial * Investigational drug treatment in the 3 months prior to the trial