Study of the PAS-Port® Proximal Anastomosis System in Coronary Bypass Surgery

PRE-OPERATIVELY Inclusion Criteria: * Able to give informed consent, able to understand the intent and clinical meaning of the study as well as its implications. Patient is legally competent. * Assessment that the patient is willing and able to have follow-up visits and examinations * Age greater than or equal to 50 years and less than 85 years * Ejection fraction of \>30% * Can tolerate radiographic contrast media * Requires non-emergent coronary artery bypass with at least two vein bypass grafts intended * Coronary artery targets intended for bypass index grafts must have \>70% native stenosis * Life expectancy \>1 year Exclusion Criteria: * Patient is participating in other clinical trials that would conflict with this protocol * Unable to meet study requirements (travel, general health) * Pregnancy * Previous cardiac surgery * Requiring preoperative use of an intraaortic balloon pump * Congestive heart failure / NYHA Class IV * History of thromboembolic disease requiring ongoing anticoagulation therapy or the presence of a bleeding disorder * Acute or chronic dialysis * Creatinine of greater than 200 µmol/L (2.3 mg/dL) in the last 30 days * Documented acute or suspected systemic infection * Need for ongoing immunosuppressive therapy * Recent (less than 2 weeks) history of cerebrovascular accident * Aspirin allergy or other contraindications to aspirin use INTRA-OPERATIVELY Inclusion Criteria: * Patient is hemodynamically stable * Open chest reassessment of the revascularization strategy confirms that two vein bypass grafts are still intended * Target vessel wall properties that are suitable for performing both a hand-sewn and a PAS-Port anastomosis * Target vessel is greater than 1.8 mm in diameter at sites where anastomoses are planned * Target vessel at sites where anastomoses will be placed are free from severe calcifications or severe atheromas * The length of the vein graft(s) is adequate for both of the planned index graft revascularization strategies * Vein outside diameter and double wall thickness are between 4 and 6 mm(inclusive) and less than or equal to 1.4 mm, respectively, at the graft site intended for the PAS-Port proximal anastomosis * The vein(s) is of suitable quality to be used as a bypass graft conduit Exclusion Criteria: -Any of the Intra-operative Inclusion Criteria not met