The purpose of this study is to determine if there is greater blood pressure reduction using ramipril or hydrochlorothiazide alone or ramipril and hydrochlorothiazide together.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Compare the effects on sitting diastolic blood pressure of two antihypertensive drugs in combination against each antihypertensive alone after an eight week treatment period.
Compare the effect on sitting diastolic blood pressure of two antihypertensive drugs in combination taken once daily against one antihypertensive drug taken twice daily.
Compare the effect on sitting diastolic blood pressure of a dose of an antihypertensive drug taken once daily against half of the same dose taken twice daily.
Compare the effect on the sitting and standing blood pressure among all treatment groups.
Compare the safety of each medication regimen stated above.
Compare the effect on mean 24-hour diastolic blood pressure (ABPM) of the medication regimens stated above.
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Huntsville, Alabama, United States
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Glendale, Arizona, United States
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Beverly Hills, California, United States
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Beverly Hills, California, United States
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Buena Park, California, United States
Marin Endocrine Care and Research
Greenbrae, California, United States
Memorial Research Medical Clinic
Long Beach, California, United States
The Intermed Group; Samaritan Medical Tower
Los Angeles, California, United States
National Research Institute
Los Angeles, California, United States
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