Critically injured patients endure a period of hypermetabolism/catabolism after being resuscitated. The metabolic cost of this may be measured in loss of lean body mass, poor wound healing, susceptibility to infection and long hospital stays. While there have been some data to suggest that hypermetabolism can be ameliorated in burn patients by beta blockade, to our knowledge, a prospective trial in trauma patients has not yet been done. Our hypothesis is that nonselective beta blockade will reduce catabolism, improve glucose control, blunt loss of lean body mass, decrease infections and improve outcome in a cohort of critically injured patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
15
Denver Health Medical Center
Denver, Colorado, United States
Change in REE vs. Controls
Time frame: ICU admission date to ICU discharge or death
Changes in Protein Metabolism Measurements
net nitrogen balance, fat-free mass, and fat mass
Time frame: ICU admission date to ICU discharge or death
Alterations in Neuroendocrine and Immunoinflammatory Measurements
blood glucose levels, insulin requirements, cortisol levels, IL-6 and IL-10 levels, infection rates, and organ dysfunction
Time frame: ICU admission date to ICU discharge or death
Clinical Outcome Measurements
Ventilator days, ICU and hospital days, and in-hospital mortality
Time frame: ICU admission date to ICU discharge or death
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