The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients

CHU de Charleroi64 enrolled

Overview

To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of diuretics) in cirrhotics with increased sympathetic nervous system. Secondary objectives were to study neuro-hormonal,hemodynamic effects and side effects of clonidine and diuretics.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Ascitic Cirrhosis Hyperactivation of Sympathetic Nervous System

Interventions

clonidineDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cirrhotic patients with ascites * Plasma norepinephrine level \> 300 pg/mL (normal value: 185 - 275 pg/mL) Exclusion Criteria: * Serum bilirubin concentration above 4.5 mg/dL * Prothrombin time below 40% * Platelet count below 40 X 10¨9/liter * Serum creatinine concentration above 2 mg/dL * Gastro-intestinal hemorrhage * Alcoholic hepatitis * Diabetes mellitus, * Hepatocellular carcinoma * Respiratory or cardiac failures * Hepatic encephalopathy * Bacterial infection

Locations (1)

ISPPC CHU de Charleroi

Charleroi, Belgium

Data from ClinicalTrials.gov

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