Safety and Effects of Ramipril Combined With Candesartan

Gachon University Gil Medical Center40 enrolled

Overview

we hypothesized that combination therapy has additive beneficial effects to improve endothelial dysfunction and adipocytokine profiles in patients with hypertension.

Forty patients will be given ramipril 10 mg and placebo, ramipril 10 mg and candesartan 16 mg, or candesartan 16 mg and placebo daily in a randomized, double-blind, placebo-controlled cross-over trial with three treatment arms and two washout periods (each 2 months).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Hypertension

Interventions

ramipril, candesartanDRUG

Eligibility

Sex: ALLMin age: 35 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with mild to moderate hypertension Exclusion Criteria: * We will exclude patients with severe hypertension, unstable angina, acute myocardial infarction, or renal insufficiency.

Outcomes

Primary Outcomes

comparison of endothelium-dependent dilation among the 3 treatment schemes

Data from ClinicalTrials.gov

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