Safety and Ocular Pharmacokinetics After 1 Drop of T1225 0.5, 1 and 1.5% in 48 Healthy Volunteers

Inclusion Criteria: * Male or female aged from 18 to 45 years old; * Written informed consent; * Healthy volunteers (without any ocular symptom); * Normal ocular examination in both eyes (corrected visual acuity (VA) \>= 6/10 - slit lamp examination without clinical relevant abnormalities - tear break-up time (BUT) \>= 10 seconds - lachrymal secretion in the Schirmer test \>= 10 mm in 5 minutes - lissamine green test total score \< 4). Exclusion Criteria: * Ocular trauma, infection or inflammation within the last 3 months; * Conjunctival hyperaemia score \>= 2, watering score \>= 2, folliculo-papillary conjunctivitis score \>= 2, number of fluorescein-stained punctuations \>= 10; * Blepharitis, conjunctivitis, uveitis; * Ocular laser treatment within the last 3 months; * Ocular surgery, including LASIK and PRK, within the last 12 months; * Topical ocular treatment during the last month; * Ocular antibiotics within the last 7 days; * Medication during the study (except paracetamol and contraceptives).