Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

Danish Headache Center15 enrolled

Overview

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

To investigate headache score and accompanying symptoms during and after infusion of carbachol. Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)

Study Type

OBSERVATIONAL

Enrollment

Conditions

Headache

Interventions

carbacholDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * Aged 18-40 * 50-100 kg * Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen. Exclusion Criteria: * Tension type headache more than once/month * Other primary headaches * Daily medication except contraceptives * Drug taken within 4 times the halflife for the specific drug except contraceptives * Pregnant or lactating women * Exposure to radiation within the last year * Headache within the last 24 hours before start of trial * Hypertension * Hypotension * Respiratory or cardiac disease

Locations (1)

Dansih Headache Center

Glostrup Municipality, Denmark

Data from ClinicalTrials.gov

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