One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy

Inclusion Criteria - 1. Histologically or cytologically proven solid tumor malignancy as proven by referral CT scan of the chest, abdomen and pelvis. 2. Patients must be refractory to standard chemotherapy or for whom no standard treatment exists. At least four weeks must have elapsed since completion of any prior chemotherapy. 3. Patients must have measurable disease; defined as at least one lesion whose longest diameter can be accurately measured as \>2 cm. 4. ECOG performance status of 0 or 1. 5. Prior locoregional therapy, including cryotherapy, radiofrequency ablation, or regional chemotherapy is allowed if at least 6 weeks have elapsed. 6. Prior radiation therapy is allowed. At least 6 weeks must have elapsed since the completion of radiation therapy and the patient must have recovered from side effects. 7. Prior systemic radionuclide therapy is allowed. At least 4 weeks must have elapsed since completion of the therapy. 8. Prior surgery is allowed. At least 6 weeks must have elapsed since the completion of major surgery and the patient must be fully recovered from this surgery and any attendant postsurgical complications. 9. Patients must be 18 years of age or older 10. Patients of childbearing potential must use adequate birth control measures (e.g., abstinence, barrier method with spermicide; or use by partner of oral contraceptives, intrauterine device, implantable or injectable contraceptives \[i.e., Norplant or Depo-Provera\] or surgical sterilization) for the duration of the study and should continue such precautions for 12 months after receiving treatment. 11. Screening physical exam must be obtained less than 7 days prior to treatment and the results must meet the following criteria: 1. Temperature range: \< 38.0 and greater and \>36.0 2. Respiratory rate: 10-20 breaths per minute 3. Heart rate: 50 - 85 beats per minute 4. Blood pressure: Systolic blood pressure greater than 90 mm Hg and less than 155 mm Hg 5. % oxygen saturation by pulse oximetry: \>93% 12. Screening laboratory tests will be obtained less than 7 days prior to treatment and the results must meet the following criteria: 1. WBC \> 3500/ mm3 and /or ANC \> 1500/ mm3, and Platelet count 100,000/ mm3. 2. Serum creatinine \< 1.5X upper limit of normal (ULN). 3. AST or ALT \< 2.5X ULN, Alkaline phosphatase \< 2.5X ULN, and Bilirubin \< 1.5X ULN. 4. INR \< 1.3 5. Hemoglobin \> 10.0 g/dL 13. Negative serum pregnancy test for females of childbearing potential. 14. The patient must be capable of giving informed consent and the consent must be obtained prior to any other screening procedures that are not considered standard procedures in this patient population. 15. A baseline transthoracic echocardiogram demonstrating a left ventricular ejection fraction (LVEF) greater than 50% and no significant valvular disease (Subjects with trace or mild valvular stenosis or regurgitation will be permitted to enroll in the study). 16. Patient is able to stay within 45 minutes driving time of Johns Hopkins Hospital for 28 days following spore injection and the 7 day in-patient hospitalization period. 17. Patient is able to stay within 45 minutes driving time of Johns Hopkins Hospital for at least 35 days after recovery from all adverse events. Exclusion Criteria - 1. Weight \> 135 kg 2. Chronic renal failure requiring hemodialysis or peritoneal dialysis 3. Patients with renal cysts. 4. Tumor lesion that is not accessible to percutaneous drainage. 5. Any single contiguous lesion greater than \> 12.5 cm (largest diameter). 6. The sum of the largest cross-sectional diameters from any number of non-contiguous lesions \> 2 cm cannot be \> 25 cm. 7. Use of any investigational drug within 30 days prior to screening or within 5 half-lives of the investigational agent, whichever is longer. 8. Any documented evidence of primary brain malignancy or brain metastases 9. Patients with any clinically significant ascites or portosystemic hypertension, chronic jaundice or cirrhosis. 10. Patients with indwelling intrahepatic arterial pumps 11. Patients with prosthetic joints, prosthetic valves, pacemakers or any other implanted foreign materials. (non-CNS surgical clips or staples are excluded) 12. Patients with any clinically significant pleural effusions 13. Patients with any evidence of hemodynamic compromise from a pericardial effusion, circumferential pericardial effusion, or any effusion greater than 1.0 cm at any location around the heart. 14. Documented cirrhosis of the liver by clinical scenarios encompassing radiographic,clinical and laboratory results 15. Ongoing treatment with any immunosuppressive agent(s) 16. Any evidence of serious infections (such as pneumonia or pyelonephritis) or history of chronic or recurrent infectious disease in the previous 3 months. Less serious infections (such as acute upper respiratory tract infection(colds)or simple urinary tract infection) can be included upon the discretion of the investigator. 17. Patients with opportunistic infections, including but not limited to evidence of active cytomegalovirus, Tuberculosis, active Pneumocystis carinii, Aspergillosis,histoplasmosis, or atypical mycobacterium infection, within the previous 6 months. 18. Documented HIV infection. 19. Active or chronic Hepatitis B or Hepatitis C. 20. Presence of a transplanted solid organ (with the exception of a corneal transplant \> 3 months prior to screening). 21. History of an autoimmune disorder (eg, systemic lupus, pemphigus vulgaris,myasthenia gravis) ), requiring medication. 22. History of Diabetes Mellitus (type I or II) 23. History of rheumatic fever, endocarditis, or greater than mild valvular disease. 24. Patients who depend upon COX II inhibitors or NSAIDS 25. History of ongoing and active arterial vasculopathy (i.e. coronary artery disease, vasculitis, diabetic vasculopathy \[i.e. retinopathy, nephropathy, etc.\]) or evidence of end organ damage (visual loss, azotemia, and cutaneous ulcerations). 26. History of an ischemic insult in the previous 12 months (myocardial infarction, cerebra vascular accident, ischemic tissue from injury or peripheral vascular disease) 27. History of venous or lymphatic stasis resulting in venous stasis ulcers or greater than 2+ edema or lymphedema. 28. History of a significant medical illness deemed by the principal investigator or sub-investigators as unsuitable for the trial - for example: 1. Symptomatic congestive heart failure 2. Psychiatric Illness/Social Situation that may make study dangerous 3. Unstable angina pectoris 29. History of a splenectomy 30. Patients with a documented Penicillin or Metronidazole allergy 31. Patients with a documented allergy to radiology contrast dye. 32. Patient with active diverticulitis 33. Patient with active dental abscesses 34. Patients with inflammatory bowel disease (IBD) 35. Women who are pregnant, lactating or breast feeding 36. Patients with angiosarcoma 37. Patients with history of a positive PPD, past TB infection or past atypical mycobacterium infection.