Dose Finding Study Of Oral Eltrombopag In Patients With Sarcoma Receiving Adriamycin And Ifosfamide

Inclusion criteria: * Adult subjects, 18 years or older * Adequate liver and kidney function * Prior history of ≥grade 2 thrombocytopenia (platelet nadir ≤ 75,000/microliters) * Ability to ingest and retain oral medication * Practice acceptable birth control * Ability to understand and follow study requirements * Life expectancy of at least 3 months Exclusion criteria: * History of platelet disorders, dysfunction, or a bleeding disorder * Anti-coagulant used within 2 weeks prior to study start * Females who are lactating or expecting * History of thromboembolic events or drug induced thrombocytopenia * History of central nervous system, brain and/or leptomeningeal metastases * Prior surgery within 2 weeks or radiotherapy within 4 weeks of study start * Pre-existing cardiac disease