MGCD0103 is an experimental drug that belongs to a class of drugs known as the histone deacetylase inhibitors, which may restore normal control in cancer cells by affecting the genes and proteins that are being made. Laboratory tests show that this new investigational anti-cancer drug can slow down the growth of human cancer cells in mice; two clinical research studies are currently being performed in humans with cancer and a similar study is being performed in patients with the same disease. The purpose of this study is to find out what effect the experimental drug MGCD0103 has on patients with relapsed and refractory Hodgkin's lymphoma.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
51
MGCD0103 administered orally three times per wek
Rush University Medical Center
Chicago, Illinois, United States
Nebraska Medical Center
Omaha, Nebraska, United States
MD Anderson Cancer Center
Houston, Texas, United States
Princess Margaret Hospital
Toronto, Ontario, Canada
Royal Victoria Hospital
Montreal, Quebec, Canada
Success rate
Time frame: 1 year (anticipated)
Progression-free survival
Time frame: 1 year (anticipated)
Duration of objective response
Time frame: 1 year (anticipated)
Safety profile
Time frame: 1 year (anticipated)
Pharmacodynamics (biomarkers)
Time frame: 1 year (anticipated)
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