AVANDAMET Versus Metformin And Sulphonylurea In People With Poorly Controlled Type 2 Diabetes

Inclusion criteria: * Body mass index \> or = to 25 kg/m2. * HbA1c \> or =7% and \< or =10% at screening. * FPG \> or = 7.0mmol/L (126mg/dL) at visit 2. * Receiving at least 0.85g of metformin at constant dose(s) for at least 8 weeks prior to visit 1a. * Female subjects must be postmenopausal or using effective contraceptive measures. Exclusion criteria: * Use of any other oral antidiabetic drug other than metformin within 12 weeks prior to screening. * Subjects with clinically significant ongoing oedema requiring pharmacological treatment or with a history of oedema requiring pharmacological treatment. * Subjects with a history of severe hypoglycaemia. * Renal disease or renal dysfunction. * Presence of clinically significant hepatic disease. * Presence of unstable or severe angina or known NYHA grade I-IV congestive heart failure. * Subjects who have had a previous myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass graft or cerebrovascular accident within 3 months prior to screening.