Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

Medical University of Vienna10 enrolled

Overview

The aim of this study is to determine if oxytocin administration is able to blunt LPS induced increase of cytokines (TNF-α) and if there is a change in the endocrine response after lipopolysaccharide administration in humans.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sepsis

Interventions

oxytocinDRUG

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men aged 18 years or older with no disease history * Written informed consent Exclusion Criteria: * Receiving any medication * Probands who suffer from infectious disease

Locations (1)

Medical University of Vienna

Vienna, Austria

Outcomes

Primary Outcomes

TNF-alpha

Time frame: six hours

Secondary Outcomes

ACTH, cortisol, procalcitonin, IL-1ra, IL-4, IL-6, MIP-1alpha, MIP-1 beta, MCP-1, IP-10, VEGF, body temperature, BNP, Ghrelin,

Time frame: six hours

Data from ClinicalTrials.gov

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