Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris

Hadassah Medical Organization40 enrolled

Overview

The concept behind our study was to combine an effect of antibiotic and anti-inflammatory agents for a more efficient acne therapy directed at the factors involved in the pathophysiology of the disease. For this purpose we evaluated a combination of clindamycin phosphate and salicylic acid in a non-irritating carrier.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Acne Vulgaris

Interventions

clindamycin phosphateDRUG

salicylic acidDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * mild to moderate acne vulgaris; * at least 5 lesions on the face; * a one-month wash-out period was established for any topical or systemic drug use for treatment of acne vulgaris. Exclusion Criteria: * acne that was primarily truncal, nodular, or due to secondary causes/internal disease; * pregnancy, breastfeeding, or intention to become pregnant; * another dermatological disease of the face; * significant systemic disease; * any drug/alcohol addiction; * interacting medication; * known hypersensitivity to study medications; * history of chronic disease treated with medications which might affect acne condition and treatment outcome (e.g. corticosteroids, lithium, isoniazid, anti-androgens, phenytoin, phenobarbital) in the preceding month

Locations (1)

Hadassah Medical Organization

Jerusalem, Israel

Outcomes

Primary Outcomes

Lesions count at the baseline (week 0)

Lesions count at the end of study (week 8)

Data from ClinicalTrials.gov

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