People with allergies frequently complain of a loss or reduction in the sense of smell. In this study, the investigators propose to perform a randomized, double blind, placebo controlled parallel study of subjects with nasal allergies and decreased smell to determine the effect of a treatment for allergies on the sense of smell.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
17
2 puffs in each nostril once daily of nasal spray
2 puffs in each nostril once daily of nasal spray
University of Chicago
Chicago, Illinois, United States
Histological Findings
Number of eosinophils per high-powered field (HPF) in olfactory biopsy taken after 2 weeks of study treatment (higher values indicate greater inflammation); average of three HPF reported
Time frame: 2 weeks
Change From Baseline in Total Nasal Symptom Score at 2 Weeks
A decrease in scores between visits signifies an improvement in nasal symptoms. The total nasal symptom score can range from 0 to 27.
Time frame: baseline and 2 weeks
Change From Baseline in Nasal Peak Inspiratory Flow at 2 Weeks
An increase between visits indicates improved nasal airflow.
Time frame: baseline and 2 weeks
Change From Baseline in Percentage of Eosinophils at 2 Weeks
A decrease between visits signifies a reduction in inflammation. Calculated from cytology specimens obtained by lavage.
Time frame: baseline and 2 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.