Carotid ultrasound can reveal the intima-media complex thickness(IMT), that has been reported to be a marker of atherosclerosis as well as a risk of cardiovascular events, and to be attenuated by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) . This substudy of J-STARS will observe the temporal profile of carotid IMT prospectively in the patients with prescription of pravastatin and the control.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
854
Hiroshima University Hospital
Hiroshima, Hiroshima, Japan
National Cardiovascular Center (NCVC)
Suita-shi, Osaka, Japan
Intima-media complex thickness (IMT) of the common carotid artery (CCA)
Time frame: until the last day of the next February after 5-year follow-up survey
Plaque score, number of plaque, recurrent cerebrovascular events
Time frame: until the last day of the next February after 5-year follow-up survey
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